Negative regulation of inclusion body assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL31RA, SPATA6L, and KRT8P43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inclusion body assembly activity versus IL31RA in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IL31RA →	-1.031	-0.154	<.001	<.001	3	4
BRCA	SPATA6L →	+0.696	+0.191	<.001	<.001	3	4
UCEC	KRT8P43 →	+0.632	+0.209	<.001	<.001	3	4
BRCA	HLA-DQA2 →	-1.372	-0.212	.002	<.001	3	3
UCEC	LPAR3 →	+1.817	+0.250	<.001	<.001	3	3
LSCC	LINC02360 →	+0.603	+0.149	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090084 vs IL31RA — LUAD

Explore this scatter interactively →