Negative regulation of inclusion body assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAIN1, GIMAP2, and MBNL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLAIN1 grouped by Negative regulation of inclusion body assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLAIN1 →	-1.807	-1.060	.003	.002	3	4
BLOOD_Lymphoma	GIMAP2 →	+2.850	+1.736	.002	<.001	3	4
LUNG_SCLC	MBNL3 →	-1.925	-0.968	.007	.002	3	4
LUNG_SCLC	NTM →	-1.996	-1.407	.002	<.001	3	4
BLOOD_Myeloma	ZC3H6 →	-1.204	-1.330	.005	.009	2	5
KIDNEY	MIA3 →	+0.636	+1.167	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLAIN1 by Negative regulation of inclusion body assembly activity — SKIN

Explore this box plot interactively →