Regulation of inclusion body assembly

Across TCGA patient cohorts, RNA activity of the Regulation of inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP4, GAS8, and TDGF1P5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inclusion body assembly activity versus SCAMP4 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCAMP4 →	+0.528	+0.143	<.001	.007	3	4
COAD	GAS8 →	+0.276	+0.127	<.001	.009	3	3
COAD	TDGF1P5 →	+0.318	+0.173	.001	.004	3	3
COAD	TSPOAP1 →	+1.140	+0.258	<.001	<.001	3	3
LUAD	RARS1 →	-0.289	-0.161	.004	.001	3	3
LUAD	TXN →	-0.730	-0.197	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090083 vs SCAMP4 — UCEC

Explore this scatter interactively →