Regulation of inclusion body assembly

Across TCGA cell cohorts, RNA activity of the Regulation of inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT8, RTL8C, and CHRNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT8 grouped by Regulation of inclusion body assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACOT8 →	+0.730	+0.177	<.001	.004	3	6
BLOOD_Lymphoma	RTL8C →	+3.304	+0.340	.003	<.001	3	5
LUNG_NSCLC_LUSC	CHRNB1 →	+1.786	+0.317	.009	.005	3	4
STOMACH	TMEM25 →	+2.383	+0.231	.004	.001	3	4
STOMACH	UBA7 →	+1.832	+0.190	<.001	.001	3	4
BLOOD_Lymphoma	TRIP10 →	+1.387	+0.260	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT8 by Regulation of inclusion body assembly activity — STOMACH

Explore this box plot interactively →