Regulation of inclusion body assembly

Across TCGA cell cohorts, RNA activity of the Regulation of inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTERF2, EGFR, and CD22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inclusion body assembly activity versus MTERF2 in SOFT_TISSUE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MTERF2 →	+1.010	+0.394	.005	.002	3	5
SOFT_TISSUE	EGFR →	-3.325	-0.371	<.001	<.001	3	5
LARGE_INTESTINE	CD22 →	-1.465	-0.413	<.001	.006	3	4
BLOOD_Lymphoma	PMM1 →	+0.609	+0.275	.003	.009	3	4
BLOOD_Myeloma	PRKACA →	+0.906	+0.288	.006	.007	2	5
BLOOD_Myeloma	FOXD1 →	-2.276	-0.346	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090083 vs MTERF2 — SOFT_TISSUE

Explore this scatter interactively →