Relaxation of muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of muscle pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA8, ADH1B, and GNA14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of muscle activity versus ABCA8 in HNSC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABCA8 →	+1.073	+0.474	<.001	<.001	3	7
PDAC	ADH1B →	+0.963	+0.214	<.001	<.001	3	7
CCRCC	GNA14 →	+0.588	+0.428	<.001	<.001	3	6
CCRCC	COX7A1 →	+1.086	+0.685	<.001	<.001	3	6
GBM	PTGDS →	+1.179	+0.278	<.001	<.001	3	6
CCRCC	RCAN2 →	+1.144	+0.543	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090075 vs ABCA8 — HNSC

Explore this scatter interactively →