Relaxation of muscle

Across TCGA cell cohorts, RNA activity of the Relaxation of muscle pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPTN, ATP1B1, and ZNF286B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of muscle activity versus NPTN in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NPTN →	+1.303	+0.254	<.001	.003	3	6
OESOPHAGUS	ATP1B1 →	+2.170	+0.312	.005	.007	3	6
PANCREAS	ZNF286B →	-1.136	-0.265	.004	.004	3	6
PANCREAS	RRP12 →	-0.836	-0.298	<.001	<.001	3	6
LUNG_NSCLC_LUSC	TRMT1 →	-1.187	-0.215	.004	.002	3	6
LARGE_INTESTINE	PRR7 →	-1.245	-0.154	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090075 vs NPTN — LIVER

Explore this scatter interactively →