Negative regulation of ribosome biogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of ribosome biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1, GSN, and TGFB1I1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ribosome biogenesis activity versus CALD1 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CALD1 →	+0.553	+0.034	.002	.006	3	6
PDAC	GSN →	+0.753	+0.049	<.001	<.001	3	6
COAD	TGFB1I1 →	+0.448	+0.033	.001	.004	3	6
COAD	SVIL →	+0.343	+0.034	.001	.007	3	6
COAD	FERMT2 →	+0.572	+0.044	<.001	<.001	3	6
COAD	SVIL_S547 →	+0.836	+0.042	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090071 vs CALD1 — COAD

Explore this scatter interactively →