Negative regulation of ribosome biogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of ribosome biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN3, TIMM23, and SRGN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ribosome biogenesis activity versus PTPN3 in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTPN3 →	+0.488	+0.116	.003	.006	3	4
CCRCC	TIMM23 →	+0.259	+0.115	.002	.003	3	4
COAD	SRGN →	-0.694	-0.218	<.001	<.001	3	4
PDAC	ZC3HAV1 →	+0.264	+0.149	<.001	.004	3	3
PDAC	ETF1 →	+0.222	+0.144	.002	.005	3	3
PDAC	ANXA1 →	+0.442	+0.181	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090071 vs PTPN3 — LSCC

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