Negative regulation of ribosome biogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of ribosome biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QTRT1, GRIP1, and ASPDH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, QTRT1 grouped by Negative regulation of ribosome biogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	QTRT1 →	-0.617	-0.860	<.001	.001	3	4
KIDNEY	GRIP1 →	+1.847	+1.410	.001	.007	3	3
BLOOD_Lymphoma	ASPDH →	+0.683	+1.591	.001	<.001	3	3
SOFT_TISSUE	RSL24D1 →	+0.792	+1.326	.001	.004	3	2
SOFT_TISSUE	BTD →	-1.307	-1.438	.003	.001	3	2
OVARY	JMJD6 →	-0.830	-0.461	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QTRT1 by Negative regulation of ribosome biogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →