Positive regulation of cell cycle process

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell cycle process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, ERLEC1, and E2F2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell cycle process activity versus ILF3 in SOFT_TISSUE (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ILF3 →	+1.276	+0.213	<.001	.003	3	7
BLOOD_Lymphoma	ERLEC1 →	-0.965	-0.131	<.001	<.001	3	7
SOFT_TISSUE	E2F2 →	+2.430	+0.190	<.001	.004	3	6
BLOOD_Leukemia	H4C1 →	+0.764	+0.166	<.001	<.001	3	6
SOFT_TISSUE	NDE1 →	+1.447	+0.173	.006	.009	3	6
SOFT_TISSUE	EDEM2 →	-1.548	-0.240	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090068 vs ILF3 — SOFT_TISSUE

Explore this scatter interactively →