Positive regulation of microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Positive regulation of microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC33, INAVA, and ATMIN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of microtubule nucleation activity versus TTC33 in BLOOD_Leukemia (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTC33 →	+1.010	+1.162	<.001	<.001	3	6
LARGE_INTESTINE	INAVA →	-1.752	-0.936	.001	.004	3	6
CNS	ATMIN →	-0.565	-1.122	.007	<.001	3	5
BONE	EPAS1 →	-4.035	-1.613	.006	<.001	2	6
STOMACH	ACYP1 →	+1.154	+1.512	.005	.001	3	5
STOMACH	TRIM29 →	-4.101	-1.413	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090063 vs TTC33 — BLOOD_Leukemia

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