Positive regulation of cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG3, TNIP1, and GLA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAG3 grouped by Positive regulation of cell migration involved in sprouting angiogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BAG3 →	-0.861	-0.382	<.001	<.001	3	5
SOFT_TISSUE	TNIP1 →	-1.824	-0.371	.006	.003	3	4
SKIN	GLA →	-0.673	-0.563	.005	.005	3	3
LIVER	ZNF233 →	+0.510	+1.483	.005	.008	3	3
STOMACH	ANKRD1 →	-3.366	-0.278	<.001	.004	2	4
STOMACH	FPR2 →	-0.103	-0.598	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAG3 by Positive regulation of cell migration involved in sprouting angiogenesis activity — BONE

Explore this box plot interactively →