Positive regulation of cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, STX11, and LAMC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell migration involved in sprouting angiogenesis activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+6.088	+1.768	.001	.001	3	9
LUNG_NSCLC_LUSC	STX11 →	+1.690	+0.401	.004	.008	3	5
BREAST	LAMC1 →	+1.802	+1.118	.009	.005	3	5
BLOOD_Leukemia	TBC1D2 →	+0.893	+1.270	.001	<.001	3	5
BLOOD_Lymphoma	SYCP2 →	+0.988	+1.135	.007	.002	3	5
BLOOD_Leukemia	CAPN2 →	+2.267	+1.197	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090050 vs ANXA1 — SOFT_TISSUE

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