Regulation of cell migration involved in sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JCAD, PRKG1, and SPARC, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell migration involved in sprouting angiogenesis activity versus JCAD in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	JCAD →	+0.765	+0.791	<.001	<.001	3	9
LSCC	PRKG1 →	+0.816	+1.040	<.001	<.001	3	9
COAD	SPARC →	+1.601	+0.819	<.001	<.001	3	8
CCRCC	PCDH12 →	+0.951	+1.206	<.001	<.001	3	8
LSCC	RECK →	+0.713	+0.937	<.001	<.001	3	8
OV	CCN4 →	+1.593	+1.061	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090049 vs JCAD — HNSC

Explore this scatter interactively →