Regulation of cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPB1, COL4A3, and ALOX5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIRPB1 grouped by Regulation of cell migration involved in sprouting angiogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SIRPB1 →	-0.960	-0.736	.003	.001	3	4
CNS	COL4A3 →	+1.180	+0.772	.005	.008	3	4
PANCREAS	ALOX5 →	+3.033	+0.944	.002	.002	3	3
CNS	MYO7B →	-0.904	-0.729	.001	.009	3	3
CNS	STMN3 →	+2.308	+1.013	<.001	<.001	3	3
CNS	MGLL →	-1.652	-0.810	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIRPB1 by Regulation of cell migration involved in sprouting angiogenesis activity — CNS

Explore this box plot interactively →