Regulation of cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, TCAIM, and SMIM29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell migration involved in sprouting angiogenesis activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+4.393	+1.233	.001	.007	3	6
KIDNEY	TCAIM →	+0.790	+0.314	.004	.001	3	6
LUNG_NSCLC_LUSC	SMIM29 →	+1.186	+0.308	<.001	<.001	3	5
OESOPHAGUS	GORASP1 →	+0.647	+0.301	<.001	<.001	3	5
STOMACH	STPG1 →	+1.608	+0.346	.003	.003	3	5
LUNG_NSCLC_LUSC	HSD11B2 →	-2.475	-0.386	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090049 vs ANXA1 — SOFT_TISSUE

Explore this scatter interactively →