Tubulin deacetylation

Across TCGA patient cohorts, RNA activity of the Tubulin deacetylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL18A_S123, LARP4_S583, and SEPTIN4_S432, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tubulin deacetylation activity versus RPL18A_S123 in UCEC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL18A_S123 →	-0.454	-0.107	<.001	<.001	3	8
LUAD	LARP4_S583 →	-0.409	-0.040	.001	.002	3	8
GBM	SEPTIN4_S432 →	+0.724	+0.053	<.001	<.001	3	7
GBM	CACNA2D2 →	+0.618	+0.063	<.001	<.001	3	7
GBM	CYTH3 →	+0.308	+0.068	<.001	<.001	3	7
BRCA	DDAH1 →	+0.676	+0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090042 vs RPL18A_S123 — UCEC

Explore this scatter interactively →