Tubulin deacetylation

Across TCGA patient cohorts, RNA activity of the Tubulin deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, TPM2, and CALHM5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tubulin deacetylation activity versus MSRB3 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSRB3 →	+1.212	+0.742	<.001	<.001	3	8
BRCA	TPM2 →	+1.302	+1.086	<.001	<.001	3	8
COAD	CALHM5 →	+0.635	+0.511	.001	.002	3	8
OV	ACTA2 →	+1.569	+0.555	<.001	.003	3	7
COAD	CNN1 →	+2.001	+0.663	<.001	<.001	3	7
OV	CCN1 →	+1.364	+0.485	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090042 vs MSRB3 — COAD

Explore this scatter interactively →