Tubulin deacetylation

Across TCGA cell cohorts, RNA activity of the Tubulin deacetylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCAR2, MYBBP1A, and ITGAV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCAR2 grouped by Tubulin deacetylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCAR2 →	+0.155	+0.112	.002	.002	3	6
LUNG_NSCLC_LUAD	MYBBP1A →	-0.246	-0.117	.001	<.001	3	5
LIVER	ITGAV →	+0.661	+0.146	.001	.001	3	5
PANCREAS	PAF1 →	-0.387	-0.162	.008	.005	3	4
OVARY	PIP4K2C →	+0.182	+0.131	<.001	.008	3	4
BLOOD_Myeloma	KMT5B →	+0.231	+0.147	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCAR2 by Tubulin deacetylation activity — BREAST

Explore this box plot interactively →