Tubulin deacetylation

Across TCGA cell cohorts, RNA activity of the Tubulin deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT3, GCLM, and PHACTR3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tubulin deacetylation activity versus PLAAT3 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLAAT3 →	+1.043	+0.260	.001	.009	3	3
BLOOD_Leukemia	GCLM →	+1.271	+0.257	.001	<.001	3	3
BREAST	PHACTR3 →	-2.100	-0.490	.001	.007	3	2
BLOOD_Leukemia	EHBP1 →	+0.997	+0.236	.002	.001	3	2
BLOOD_Leukemia	VARS2 →	+0.715	+0.238	.002	.001	3	2
BLOOD_Leukemia	C6orf89 →	+0.959	+0.219	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090042 vs PLAAT3 — BLOOD_Leukemia

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