Positive regulation of protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein kinase C signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A2, COL1A2, and P3H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein kinase C signaling activity versus COL5A2 in BRCA (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL5A2 →	+0.609	+0.036	<.001	<.001	3	5
BRCA	COL1A2 →	+0.895	+0.044	<.001	<.001	3	5
BRCA	P3H1 →	+0.621	+0.049	<.001	<.001	3	5
GBM	C6 →	+0.362	+0.040	.008	.004	3	5
OV	UBL4A_S90 →	-0.736	-0.063	.001	<.001	3	5
COAD	WNT11 →	+1.732	+0.075	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090037 vs COL5A2 — BRCA

Explore this scatter interactively →