Positive regulation of protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STC1, LOX, and ARF4P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein kinase C signaling activity versus STC1 in LUAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STC1 →	+1.388	+0.451	<.001	<.001	3	4
UCEC	LOX →	+0.632	+0.577	.005	.003	3	3
OV	ARF4P2 →	+0.337	+0.911	.002	<.001	3	3
BRCA	NDUFB4P12 →	+0.670	+0.359	.005	.001	3	3
BRCA	TBC1D30 →	-0.395	-0.412	.002	.001	3	3
LUAD	RCBTB1 →	-0.235	-0.440	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090037 vs STC1 — LUAD

Explore this scatter interactively →