Positive regulation of protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein kinase C signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUBCNL, ARHGEF15, and PRC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RUBCNL grouped by Positive regulation of protein kinase C signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RUBCNL →	+0.409	+1.426	.005	.001	3	4
BREAST	ARHGEF15 →	-0.120	-0.605	<.001	.001	3	3
BREAST	PRC1 →	+0.244	+1.009	.004	.006	2	4
LUNG_SCLC	CDK9 →	-0.371	-1.533	<.001	<.001	3	3
CNS	ATP10A →	-0.220	-0.664	.003	.002	3	3
OVARY	TRPV4 →	-0.123	-0.414	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RUBCNL by Positive regulation of protein kinase C signaling activity — LUNG_SCLC

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