Negative regulation of steroid hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHACTR3-AS1, KRT8P19, and STAT5B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of steroid hormone biosynthetic process activity versus PHACTR3-AS1 in CCRCC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PHACTR3-AS1 →	+0.259	+0.646	.006	<.001	3	3
OV	KRT8P19 →	+0.068	+0.652	.004	<.001	3	3
UCEC	STAT5B →	-0.415	-0.567	.002	.007	3	3
UCEC	NSFL1C →	-0.342	-0.604	.004	.002	3	3
GBM	CLINT1 →	-0.209	-0.533	<.001	.004	3	3
GBM	GAD1 →	+1.036	+0.473	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090032 vs PHACTR3-AS1 — CCRCC

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