Negative regulation of steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS19, TECPR1, and ADAM19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS19 grouped by Negative regulation of steroid hormone biosynthetic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPS19 →	-0.989	-1.774	<.001	<.001	3	4
PANCREAS	TECPR1 →	+1.136	+1.024	.001	.004	3	4
SOFT_TISSUE	ADAM19 →	+3.245	+1.236	.007	.006	3	4
UPPER_AERODIGESTIVE_TRACT	H3C8 →	-0.801	-1.331	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ITPRIP →	+1.226	+1.035	.008	.002	3	4
BLOOD_Leukemia	BBC3 →	-1.818	-1.288	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS19 by Negative regulation of steroid hormone biosynthetic process activity — UPPER_AERODIGESTIVE_TRACT

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