Negative regulation of steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of steroid hormone biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRAME, IREB2, and ARHGDIG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRAME grouped by Negative regulation of steroid hormone biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRAME →	-0.151	-0.706	.009	.004	3	3
STOMACH	IREB2 →	-0.301	-0.988	.001	.003	3	3
STOMACH	ARHGDIG →	-0.302	-0.959	<.001	.008	3	3
OVARY	CYP27C1 →	-0.177	-0.932	<.001	<.001	3	3
PANCREAS	NT5DC1 →	+0.213	+1.440	.002	<.001	3	3
LUNG_SCLC	HBEGF →	-0.242	-1.339	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRAME by Negative regulation of steroid hormone biosynthetic process activity — BREAST

Explore this box plot interactively →