Regulation of steroid hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, MIS18A, and MELK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid hormone biosynthetic process activity versus MCM4 in PDAC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MCM4 →	-0.568	-0.750	<.001	.001	3	6
LUAD	MIS18A →	-0.427	-0.522	.003	.001	3	5
PDAC	MELK →	-0.803	-0.793	<.001	<.001	3	5
LSCC	POLR1C →	-0.508	-0.693	.005	.001	3	5
LUAD	XRCC2 →	-0.705	-0.598	.001	<.001	3	5
LUAD	KIFC1 →	-0.862	-0.705	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090030 vs MCM4 — PDAC

Explore this scatter interactively →