Regulation of steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4ENIF1, PPP1R13L, and HSPBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4ENIF1 grouped by Regulation of steroid hormone biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EIF4ENIF1 →	+1.051	+1.520	.004	.002	3	4
STOMACH	PPP1R13L →	-2.882	-1.098	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	HSPBP1 →	-0.958	-1.071	<.001	<.001	3	4
OESOPHAGUS	ZSCAN5C →	+0.020	+0.972	.009	.005	3	4
BONE	TUBB →	+0.688	+1.625	<.001	<.001	3	4
BONE	KIFC1 →	+0.913	+1.618	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4ENIF1 by Regulation of steroid hormone biosynthetic process activity — BLOOD_Myeloma

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