Regulation of steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE9A, GBE1, and SNAPC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid hormone biosynthetic process activity versus PDE9A in STOMACH (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDE9A →	+3.144	+0.529	<.001	.006	3	4
LUNG_NSCLC_LUAD	GBE1 →	-1.048	-0.350	.001	<.001	3	4
OESOPHAGUS	SNAPC2 →	-0.925	-0.400	.006	.002	3	4
LARGE_INTESTINE	UGGT1 →	-0.940	-0.354	.002	.001	2	4
PANCREAS	MKRN2 →	-0.872	-0.168	.008	.007	3	3
OVARY	H4-16 →	+1.377	+1.350	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090030 vs PDE9A — STOMACH

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