Negative regulation of monocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISLR, LGALS1_S30, and SPON1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte chemotaxis activity versus ISLR in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ISLR →	+0.637	+0.115	<.001	<.001	3	8
BRCA	LGALS1_S30 →	+0.848	+0.053	<.001	<.001	3	8
UCEC	SPON1 →	+0.948	+0.103	<.001	<.001	3	7
BRCA	TLN2 →	+0.496	+0.056	<.001	<.001	3	7
BRCA	VCL_S795 →	+0.488	+0.073	<.001	<.001	3	7
CCRCC	ADAMTSL4 →	+0.507	+0.084	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090027 vs ISLR — GBM

Explore this scatter interactively →