Negative regulation of monocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GREM1, DCHS1, and SYDE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte chemotaxis activity versus GREM1 in LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GREM1 →	+1.415	+0.949	<.001	<.001	3	6
LUAD	DCHS1 →	+0.405	+0.693	.003	.001	3	6
BRCA	SYDE1 →	+0.736	+0.584	<.001	.001	3	6
BRCA	LMOD1 →	+1.216	+0.840	<.001	<.001	3	6
LSCC	FBN1 →	+1.029	+0.703	<.001	.001	3	6
COAD	POPDC2 →	+0.922	+0.274	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090027 vs GREM1 — LUAD

Explore this scatter interactively →