Negative regulation of monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VMP1, LXN, and C8G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VMP1 grouped by Negative regulation of monocyte chemotaxis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VMP1 →	+1.314	+1.402	.002	<.001	3	5
SKIN	LXN →	-2.537	-1.097	.006	<.001	3	4
OESOPHAGUS	C8G →	+0.834	+1.038	.002	.001	3	4
LIVER	RAB4A →	-0.483	-1.324	.001	.009	3	4
CNS	PMEPA1 →	+2.221	+0.879	.005	.009	3	3
CNS	AZU1 →	+0.272	+0.922	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VMP1 by Negative regulation of monocyte chemotaxis activity — STOMACH

Explore this box plot interactively →