Positive regulation of monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBTD1, AGPS, and OLFML2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monocyte chemotaxis activity versus UBTD1 in BREAST (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UBTD1 →	-1.223	-0.299	<.001	.003	3	6
BREAST	AGPS →	-1.657	-0.272	.002	.004	3	6
BONE	OLFML2A →	-2.107	-0.552	<.001	.005	3	5
BREAST	TIMP2 →	-3.023	-0.320	.001	.003	3	5
LUNG_NSCLC_LUAD	PLIN3 →	-0.918	-0.581	.001	.004	3	5
BREAST	SLX1A →	+0.906	+0.351	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090026 vs UBTD1 — BREAST

Explore this scatter interactively →