Regulation of neutrophil chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of neutrophil chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN3, WAS, and WIPF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil chemotaxis activity versus RIN3 in UCEC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RIN3 →	+0.410	+0.058	<.001	<.001	3	10
UCEC	WAS →	+0.511	+0.055	<.001	<.001	3	10
UCEC	WIPF1 →	+0.425	+0.056	<.001	<.001	3	10
CCRCC	ADA2 →	+0.480	+0.038	<.001	<.001	3	10
UCEC	CRLF3 →	+0.343	+0.053	<.001	<.001	3	10
LSCC	DOCK2 →	+0.522	+0.077	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090022 vs RIN3 — UCEC

Explore this scatter interactively →