Regulation of neutrophil chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of neutrophil chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, CEACAM4, and MS4A6A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil chemotaxis activity versus FCGR2A in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR2A →	+0.739	+0.158	<.001	<.001	3	7
LSCC	CEACAM4 →	+0.591	+0.213	<.001	<.001	3	6
GBM	MS4A6A →	+0.753	+0.135	<.001	<.001	3	6
GBM	MS4A4A →	+0.885	+0.158	<.001	<.001	3	6
GBM	TYROBP →	+0.726	+0.137	<.001	<.001	3	6
OV	IGLV7-43 →	+1.797	+0.187	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090022 vs FCGR2A — GBM

Explore this scatter interactively →