Regulation of neutrophil chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, TMEM144, and SGK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil chemotaxis activity versus CSNK1G2 in KIDNEY (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CSNK1G2 →	+0.750	+0.376	.005	<.001	3	4
SKIN	TMEM144 →	-0.879	-0.251	.008	.003	3	4
OVARY	SGK2 →	+1.939	+0.256	.002	.002	3	4
KIDNEY	IL4R →	+0.905	+0.309	.001	<.001	3	4
BREAST	SYCP2 →	-2.559	-0.250	<.001	.002	3	4
BLOOD_Myeloma	SLC2A4RG →	-1.845	-0.467	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090022 vs CSNK1G2 — KIDNEY

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