Primitive streak formation

Across TCGA patient cohorts, RNA activity of the Primitive streak formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLTP, CCDC88C, and CEP170_S359, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primitive streak formation activity versus GLTP in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLTP →	+0.354	+0.095	.006	.006	3	5
HNSC	CCDC88C →	+0.352	+0.128	<.001	<.001	3	5
HNSC	CEP170_S359 →	-0.310	-0.127	.005	<.001	3	5
BRCA	SYNPO →	+0.360	+0.091	<.001	<.001	3	4
OV	WNT5A →	+1.043	+0.101	<.001	<.001	3	4
LSCC	BICD2_S823 →	+0.816	+0.101	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090009 vs GLTP — LSCC

Explore this scatter interactively →