Primitive streak formation

Across TCGA patient cohorts, RNA activity of the Primitive streak formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AREL1, ADAM23, and RORA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primitive streak formation activity versus AREL1 in UCEC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AREL1 →	-0.399	-0.504	<.001	.002	3	3
HNSC	ADAM23 →	+0.998	+0.573	.008	.004	3	3
HNSC	RORA →	+0.491	+0.598	<.001	<.001	3	3
BRCA	EVI2A →	+0.626	+0.606	<.001	.003	3	3
BRCA	GRAP2 →	+0.415	+0.430	.006	.005	3	3
BRCA	IL18R1 →	+0.627	+0.387	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090009 vs AREL1 — UCEC

Explore this scatter interactively →