Primitive streak formation

Across TCGA cell cohorts, RNA activity of the Primitive streak formation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZACN, PMVK, and NDUFA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZACN grouped by Primitive streak formation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZACN →	-1.074	-1.066	.008	.007	3	4
BLOOD_Lymphoma	PMVK →	-0.770	-2.170	<.001	<.001	3	3
LUNG_NSCLC_LUSC	NDUFA5 →	-0.633	-1.466	.003	.001	3	3
STOMACH	MRPL11 →	+0.824	+1.250	<.001	.001	3	3
LUNG_NSCLC_LUSC	DLD →	-0.931	-1.312	<.001	.007	3	3
BLOOD_Leukemia	CSNK1A1 →	+0.772	+1.183	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZACN by Primitive streak formation activity — KIDNEY

Explore this box plot interactively →