Amino acid import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Amino acid import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL14A1, MGP, and CHRDL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid import across plasma membrane activity versus COL14A1 in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL14A1 →	-1.307	-0.290	<.001	.004	3	5
HNSC	MGP →	-1.254	-0.423	<.001	<.001	3	5
BRCA	CHRDL1 →	-1.655	-0.840	<.001	<.001	3	5
HNSC	DDR2 →	-0.652	-0.319	.004	.004	3	5
HNSC	FRZB →	-0.831	-0.327	.002	.003	2	6
LSCC	TSPAN2 →	-0.797	-0.726	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0089718 vs COL14A1 — GBM

Explore this scatter interactively →