Amino acid import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Amino acid import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and A4GALT, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid import across plasma membrane activity versus SLC7A5 in LUNG_NSCLC_LUAD (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC7A5 →	+1.965	+0.322	<.001	<.001	3	11
OVARY	SLC3A2 →	+1.329	+0.329	.001	.001	3	9
LIVER	A4GALT →	+2.268	+0.402	.006	.003	3	5
LARGE_INTESTINE	CAPN5 →	-1.603	-0.239	.005	<.001	3	5
KIDNEY	DNMBP →	-1.598	-0.336	.001	.006	3	5
LARGE_INTESTINE	TOP1MT →	-0.573	-0.200	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0089718 vs SLC7A5 — LUNG_NSCLC_LUAD

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