L-histidine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-histidine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC38A5, NUP93_S52, and CIT_S1971, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-histidine transmembrane transport activity versus SLC38A5 in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC38A5 →	+0.984	+0.096	<.001	<.001	3	6
COAD	NUP93_S52 →	-0.642	-0.071	.001	<.001	3	5
LUAD	CIT_S1971 →	-1.654	-0.071	<.001	<.001	3	5
COAD	BOD1L1_S2501 →	-0.328	-0.074	.001	<.001	3	4
COAD	ERO1A →	+0.419	+0.074	<.001	.001	3	4
GBM	ITPK1 →	+0.390	+0.070	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0089709 vs SLC38A5 — HNSC

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