L-histidine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-histidine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASL-DT, HSP90AB2P, and CLBA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-histidine transmembrane transport activity versus WASL-DT in CCRCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	WASL-DT →	-0.332	-0.564	.003	.009	3	4
LSCC	HSP90AB2P →	+0.286	+0.585	.006	.002	3	3
CCRCC	CLBA1 →	-0.368	-0.792	.007	.001	3	3
CCRCC	RGS9 →	-0.563	-0.641	.005	.003	3	3
CCRCC	SLC9B1 →	-0.260	-0.752	.009	.003	3	3
CCRCC	ZNF491 →	-0.516	-0.854	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0089709 vs WASL-DT — CCRCC

Explore this scatter interactively →