L-histidine transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-histidine transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC38A3, SLC7A1, and SLC38A5, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC38A3 grouped by L-histidine transmembrane transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC38A3 →	-0.646	-1.690	<.001	.001	3	11
STOMACH	SLC7A1 →	-0.492	-1.820	.001	<.001	3	10
STOMACH	SLC38A5 →	-0.162	-1.545	.004	<.001	2	7
PANCREAS	SLC15A4 →	-0.273	-1.818	.004	<.001	3	6
CNS	SLC25A29 →	-0.290	-1.552	<.001	<.001	3	5
LUNG_NSCLC_LUSC	VPS50 →	+0.185	+1.488	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC38A3 by L-histidine transmembrane transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →