Endothelin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Endothelin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN2, KANK3, and TNS2_S120, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelin receptor signaling pathway activity versus CAVIN2 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN2 →	+1.109	+0.075	<.001	<.001	3	9
CCRCC	KANK3 →	+0.589	+0.068	<.001	.002	3	9
OV	TNS2_S120 →	+0.730	+0.069	<.001	.001	3	8
LSCC	DMD →	+0.424	+0.084	<.001	<.001	3	8
BRCA	ITIH5 →	+0.437	+0.041	<.001	<.001	3	8
CCRCC	RASIP1 →	+0.452	+0.073	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086100 vs CAVIN2 — BRCA

Explore this scatter interactively →