Endothelin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Endothelin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAR3, RDH12, and ENO3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelin receptor signaling pathway activity versus BCAR3 in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCAR3 →	+0.753	+0.290	<.001	<.001	3	4
COAD	RDH12 →	-0.214	-0.438	.002	.001	3	3
UCEC	ENO3 →	-0.425	-0.487	.001	.001	3	3
LUAD	PMS2 →	-0.321	-0.512	<.001	.001	3	3
LUAD	CACYBPP2 →	-0.200	-0.427	.006	.008	3	3
GBM	RPL9P7 →	-0.321	-0.507	.008	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086100 vs BCAR3 — BRCA

Explore this scatter interactively →