Endothelin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Endothelin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKB, CDC42BPG, and CHPT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKB grouped by Endothelin receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CKB →	-3.209	-1.206	.002	<.001	3	4
LUNG_SCLC	CDC42BPG →	-2.257	-1.303	<.001	.003	3	4
BLOOD_Leukemia	CHPT1 →	-1.404	-1.337	.007	<.001	3	4
OESOPHAGUS	NAPSA →	-0.858	-1.168	.001	.002	3	3
LIVER	MRPL35 →	+0.471	+1.339	.009	.004	3	3
LIVER	TMEM8B →	-1.140	-1.415	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKB by Endothelin receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →