Endothelin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Endothelin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINM1, CCT2, and PTHLH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelin receptor signaling pathway activity versus GINM1 in SKIN (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GINM1 →	+0.892	+0.159	<.001	.003	2	7
LIVER	CCT2 →	-0.830	-0.484	<.001	.001	3	5
LUNG_NSCLC_LUSC	PTHLH →	+3.795	+0.263	.006	.006	3	5
OESOPHAGUS	NTF4 →	+1.526	+0.194	.002	.001	3	4
BONE	H4C8 →	+2.573	+0.518	.005	.005	3	4
LUNG_NSCLC_LUSC	LYRM2 →	-0.725	-0.276	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086100 vs GINM1 — SKIN

Explore this scatter interactively →