Bundle of His cell to Purkinje myocyte communication

Across TCGA patient cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte communication pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSP, JUP, and PKP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bundle of His cell to Purkinje myocyte communication activity versus DSP in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSP →	+0.677	+0.067	<.001	<.001	3	8
LSCC	JUP →	+0.520	+0.053	.001	.002	3	8
LUAD	PKP2 →	+0.904	+0.051	<.001	<.001	3	8
HNSC	DSG2 →	+0.511	+0.087	<.001	<.001	3	7
LUAD	PKP2_S251 →	+1.575	+0.083	<.001	<.001	3	7
GBM	DSG2_S703 →	+0.940	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086069 vs DSP — BRCA

Explore this scatter interactively →